Identify the body’s natural substances that have antimicrobial action and produce them in large quantities in laboratories for use in medical treatments, is a very interesting way to develop new drugs.
They have now discovered that certain proteins are able eye to keep out pathogens. These substances can be the basis of new antimicrobials, which also would be cheaper.
The team of specialists in vision that has made the discovery, at the University of California at Berkeley, tested synthetic versions of these proteins, derived from cytokeratin 6A, to see the extent of their action against various pathogens. These synthetic molecules annihilated the bacteria causing strep throat and some cases of necrotizing fasciitis (Streptococcus pyogenes), diarrhea and sometimes fatal infections (Escherichia coli) and infections caused by Staphylococcus aureus and Pseudomonas aeruginosa.
The cytokeratin 6A can be found in epithelial cells of the human cornea, as well as the skin, hair and nails. These are all areas of the body is constantly exposed to microorganisms, so it is reasonable that they exist in natural defensive these additional barriers.
As microbiologist Suzanne Fleiszig reasons, the research team and a professor at the University of California at Berkeley, since the substances investigated in the study are present in the body, it is obvious that they are biocompatible and without overt toxicity. They are relatively easy to manufacture. Therefore, there are good candidates for low-cost therapies.
The problem with other natural antimicrobial small molecules identified in previous studies is that they are toxic or highly in activated by normal concentrations of salt in our body.
In the new research, there have been also worked by Connie Tam, James Mun and David Evans, all from the University of California at Berkeley.
The Bill & Melinda Gates Foundation and the National Institutes of Health of United States provided support for this study.