It has been shown in a new study that an artificial substance destroys certain chemicals that induce allergic response in sensitive individuals. The finding could lead to treatments extremely powerful and fast for severe allergic reactions.
The research scientists have conducted at the School of Medicine at Stanford University in California, and the University of Bern in Switzerland.
The new inhibitor dismantles to IgE antibodies, which play a fundamental role in acute allergies. The inhibitor achieves by way of separating the antibody from its “partner in crime”, a molecule called FcR. (Other mechanisms leading to allergic reactions slower course).
This inhibitor has worked with the team of Ted Jardetzky, structural biology professor, could, in theory, become a drug to rapidly dismantle IgE antibodies in full acute allergic reaction.
A myriad of allergens from certain kinds of pollen, nuts up components, can activate IgE antibodies, producing allergic reactions in seconds. The novel inhibitor which destroys the complex binds to the IgE antibodies with the cells responsible for the reaction, called mast.
When for the first time a potential allergen penetrates inside the body, the body responds by some people that allergen IgE antibodies against real or apparent.
These antibodies persist long after the initial allergen is removed from the body. Most of the antibodies bound receptors are specifically prepared for IgE, the FcRs. Such receptors are exposed on the surface of mast cells. The mast cells are therefore prepared to react the next time a person is exposed to the allergen.
Dissociation of IgE-FcR this interaction is a highly coveted target for scientists seeking new treatments for allergy. That desire is due to a good reason: Mast cells are covered with IgE and histamine grenades. The encounter with the allergen is equivalent to pulling the ripcord of pomegranate.
When an allergen visit an organization where others of the same type as were before, IgE binds to the pre-loaded on the surface of mast cells, triggering the release of inflammatory mediators, including histamine, which promote allergic response. As you know people with allergies, these unpleasant reactions can be started in seconds. A severe allergic response can result in anaphylactic shock and cause sudden death.
The team of Jardetzky discovered an inhibitor called DARPin E2-79 separates the IgE antibody to the receiver of the mast cell. Using this inhibitor, an interaction that normally takes hours or days depending on stability, is truncated in seconds.
The investigation was also worked by Beomkyu Kim, Alexander Eggel and Svetlana Tarchevskaya.